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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 12347408
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAmultiple interactionsEXP 6480464CTD[[Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein] which results in decreased acetylation of RELA protein; [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased localization of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased localization of and results in increased activity of RELA protein]PMID:21239502
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