GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ins2 | decreases expression | EXP | | 6480464 | CTD | resveratrol results in decreased expression of INS protein | PMID:21945106 | Ins2 | increases response to substance | EXP | | 6480464 | CTD | resveratrol results in increased susceptibility to INS protein | PMID:21945106 | Ins2 | multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [INS protein results in increased uptake of Glucose]]; resveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in decreased susceptibility to INS protein] | PMID:24231106 | Ins2 | decreases response to substance | ISO | INS (Homo sapiens) | 6480464 | CTD | INS protein results in decreased susceptibility to resveratrol; resveratrol results in decreased susceptibility to INS protein | PMID:15297429 PMID:20015842 | Ins2 | increases expression | ISO | INS (Homo sapiens) | 6480464 | CTD | resveratrol results in increased expression of INS protein | PMID:23536519 | Ins2 | multiple interactions | ISO | INS (Homo sapiens) | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]]; resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]; resveratrol inhibits the reaction [INS protein results in increased expression of HIF1A protein]; resveratrol inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; resveratrol inhibits the reaction [INS protein results in increased phosphorylation of FOXO4 protein]; resveratrol inhibits the reaction [IRS2 gene mutant form inhibits the reaction [INS protein results in increased expression of IRS2 protein]]; resveratrol inhibits the reaction [IRS2 gene mutant form inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; resveratrol inhibits the reaction [IRS2 gene mutant form inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; resveratrol inhibits the reaction [Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]; SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]]; SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]] | PMID:15297429 PMID:16626303 PMID:17550345 PMID:20960276 PMID:21163946 PMID:25808216 | | ||||||||||||||||||||||
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