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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsp90b1
Name: heat shock protein 90 beta family member 1
Acc ID: CHEBI:27869
Term: chloroacetic acid
Definition: A chlorocarboxylic acid that is acetic acid carrying a 2-chloro substituent.
Chemical ID: MESH:C006972
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsp90b1increases expressionISORGD:13214106480464CTDchloroacetic acid results in increased expression of HSP90B1 mRNA; chloroacetic acid results in increased expression of HSP90B1 proteinPMID:25451595
Hsp90b1multiple interactionsISORGD:13214106480464CTDAcetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSP90B1 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]PMID:25451595
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