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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:2781
Term: apocynin
Definition: An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Chemical ID: MESH:C056165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1multiple interactionsEXP 6480464CTDacetovanillone inhibits the reaction [arsenite results in increased oxidation of PARP1 protein]; acetovanillone inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]PMID:29111459 PMID:34798142
PARP1multiple interactionsISOParp1 (Mus musculus)6480464CTDacetovanillone inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; acetovanillone inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]PMID:15502880 PMID:18509044
PARP1multiple interactionsISOParp1 (Rattus norvegicus)6480464CTD[polyethylene glycol-superoxide dismutase co-treated with acetovanillone] inhibits the reaction [EDN1 protein results in increased expression of and results in increased cleavage of PARP1 protein]PMID:24932781
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