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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311801
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Syngr3
Name: synaptogyrin 3
Acc ID: CHEBI:27808
Term: heroin
Definition: A morphinane alkaloid that is morphine bearing two acetyl substituents on the O-3 and O-6 positions. As with other opioids, heroin is used as both an analgesic and a recreational drug. Frequent and regular administration is associated with tolerance and physical dependence, which may develop into addiction. Its use includes treatment for acute pain, such as in severe physical trauma, myocardial infarction, post-surgical pain, and chronic pain, including end-stage cancer and other terminal illnesses.
Chemical ID: MESH:D003932
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Syngr3decreases expressionISOSYNGR3 (Homo sapiens)6480464CTDHeroin results in decreased expression of SYNGR3 mRNAPMID:16710320
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