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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapt
Name: microtubule-associated protein tau
Acc ID: CHEBI:27779
Term: griseofulvin
Definition: An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.
Chemical ID: MESH:D006118
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Maptincreases expressionISOMapt (Mus musculus)6480464CTDGriseofulvin results in increased expression of MAPT mRNA; Griseofulvin results in increased expression of MAPT mRNA alternative form; Griseofulvin results in increased expression of MAPT proteinPMID:10051481
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