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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10649
Species: Mus musculus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:27779
Term: griseofulvin
Definition: An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.
Chemical ID: MESH:D006118
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1increases expressionISOGJA1 (Homo sapiens)6480464CTDGriseofulvin results in increased expression of GJA1 mRNAPMID:23329179
Gja1multiple interactionsISOGJA1 (Homo sapiens)6480464CTDGriseofulvin results in increased expression of and results in increased localization of GJA1 proteinPMID:23329179
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