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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732955
Species: Mus musculus
RGD Object: Gene
Symbol: Dusp1
Name: dual specificity phosphatase 1
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dusp1decreases expressionEXP 6480464CTDGlyphosate results in decreased expression of DUSP1 mRNAPMID:35897073
Dusp1affects expressionISODUSP1 (Homo sapiens)6480464CTDGlyphosate affects the expression of DUSP1 mRNAPMID:31295307
Dusp1increases expressionISODusp1 (Rattus norvegicus)6480464CTDGlyphosate results in increased expression of DUSP1 mRNAPMID:34850229
Dusp1multiple interactionsISODusp1 (Rattus norvegicus)6480464CTD[azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of DUSP1 mRNAPMID:33854195
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