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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69229
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rack1
Name: receptor for activated C kinase 1
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rack1decreases expressionISORACK1 (Homo sapiens)6480464CTDGlyphosate results in decreased expression of RACK1 mRNAPMID:17984146
Rack1increases expressionISORack1 (Mus musculus)6480464CTDGlyphosate results in increased expression of RACK1 proteinPMID:36173347
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