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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1affects expressionISOCCND1 (Homo sapiens)6480464CTDGlyphosate affects the expression of CCND1 mRNAPMID:31295307
Ccnd1increases expressionISOCCND1 (Homo sapiens)6480464CTDGlyphosate results in increased expression of CCND1 mRNA; Glyphosate results in increased expression of CCND1 proteinPMID:24073338 PMID:29890199 PMID:31751608
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTDU 0126 inhibits the reaction [Glyphosate results in increased expression of CCND1 protein]PMID:29890199
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