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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Birc2
Name: baculoviral IAP repeat-containing 2
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Birc2decreases expressionISOBIRC2 (Homo sapiens)6480464CTDGlyphosate results in decreased expression of BIRC2 mRNAPMID:31295307
Birc2increases expressionISOBIRC2 (Homo sapiens)6480464CTDGlyphosate results in increased expression of BIRC2 mRNAPMID:31874349
Birc2multiple interactionsISOBIRC2 (Homo sapiens)6480464CTD[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of BIRC2 mRNAPMID:32800223
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