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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620657
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fat3
Name: FAT atypical cadherin 3
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fat3increases methylationEXP 6480464CTDGlyphosate results in increased methylation of FAT3 genePMID:31011160
Fat3multiple interactionsISOFat3 (Mus musculus)6480464CTD[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of FAT3 mRNAPMID:37567420
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