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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620089
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ocln
Name: occludin
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oclndecreases expressionEXP 6480464CTDGlyphosate results in decreased expression of OCLN mRNA; Glyphosate results in decreased expression of OCLN proteinPMID:34906888
Oclnmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Glyphosate results in decreased expression of OCLN protein]; NOX1 protein affects the reaction [Glyphosate results in decreased expression of OCLN protein]PMID:34906888
Oclndecreases expressionISOOCLN (Homo sapiens)6480464CTDGlyphosate results in decreased expression of OCLN proteinPMID:30605748
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