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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases expressionEXP 6480464CTDGlyphosate results in increased expression of MAPK3 mRNAPMID:32045792
Mapk3increases phosphorylationEXP 6480464CTDGlyphosate results in increased phosphorylation of MAPK3 proteinPMID:28627408
Mapk3increases expressionISOMAPK3 (Homo sapiens)6480464CTDGlyphosate results in increased expression of MAPK3 mRNAPMID:31295307
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDGlyphosate results in increased phosphorylation of MAPK3 proteinPMID:29890199
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDafimoxifene inhibits the reaction [Glyphosate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Glyphosate results in increased phosphorylation of MAPK3 protein]PMID:29890199
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