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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2933
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itpr1
Name: inositol 1,4,5-trisphosphate receptor, type 1
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itpr1decreases expressionISOITPR1 (Homo sapiens)6480464CTDGlyphosate results in decreased expression of ITPR1 mRNA; Glyphosate results in decreased expression of ITPR1 protein alternative formPMID:24073338 PMID:31295307
Itpr1increases expressionISOITPR1 (Homo sapiens)6480464CTDGlyphosate results in increased expression of ITPR1 mRNAPMID:31295307
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