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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDGlyphosate results in decreased activity of CAT proteinPMID:25403740 PMID:30821249 PMID:37328116
Catdecreases expressionEXP 6480464CTDGlyphosate results in decreased expression of CAT mRNA; Glyphosate results in decreased expression of CAT proteinPMID:31226268 PMID:32145347 PMID:34906888
Catincreases activityEXP 6480464CTDGlyphosate results in increased activity of CAT proteinPMID:23820267 PMID:25403740 PMID:28627408
Catmultiple interactionsEXP 6480464CTD[Atrazine co-treated with Glyphosate] results in decreased activity of CAT protein; NOX1 protein affects the reaction [Glyphosate results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Glyphosate results in decreased activity of CAT protein]PMID:25403740 PMID:30821249 PMID:34906888
Catdecreases activityISOCat (Mus musculus)6480464CTDGlyphosate results in decreased activity of CAT proteinPMID:30245445
Catdecreases expressionISOCat (Mus musculus)6480464CTDGlyphosate results in decreased expression of CAT proteinPMID:36608876
Catincreases expressionISOCAT (Homo sapiens)6480464CTDGlyphosate results in increased expression of CAT proteinPMID:24999230
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