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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620920
Species: Mus musculus
RGD Object: Gene
Symbol: Dnmt3a
Name: DNA methyltransferase 3A
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt3aincreases expressionISODnmt3a (Rattus norvegicus)6480464CTDGlyphosate results in increased expression of DNMT3A mRNAPMID:26302742 PMID:33512083 PMID:34542374
Dnmt3aincreases expressionISODNMT3A (Homo sapiens)6480464CTDGlyphosate results in increased expression of DNMT3A mRNAPMID:33803994
Dnmt3aincreases methylationISODnmt3a (Rattus norvegicus)6480464CTDGlyphosate results in increased methylation of DNMT3A genePMID:31011160
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