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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320375
Species: Homo sapiens
RGD Object: Gene
Symbol: HOXA10
Name: homeobox A10
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HOXA10decreases expressionISOHoxa10 (Rattus norvegicus)6480464CTDGlyphosate results in decreased expression of HOXA10 mRNAPMID:32640336
HOXA10increases expressionISOHoxa10 (Rattus norvegicus)6480464CTDGlyphosate results in increased expression of HOXA10 proteinPMID:27287056 PMID:27486271 PMID:31550491
HOXA10multiple interactionsISOHoxa10 (Rattus norvegicus)6480464CTD[Endosulfan co-treated with Glyphosate] results in increased expression of HOXA10 proteinPMID:31550491
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