Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307040
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k4
Name: mitogen activated protein kinase kinase 4
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k4affects methylationISOMAP2K4 (Homo sapiens)6480464CTDGlyphosate affects the methylation of MAP2K4 genePMID:35377194
Map2k4decreases expressionISOMAP2K4 (Homo sapiens)6480464CTDGlyphosate results in decreased expression of MAP2K4 mRNAPMID:31295307
Go Back to source page   Continue to Ontology report