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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737111
Species: Homo sapiens
RGD Object: Gene
Symbol: EGR1
Name: early growth response 1
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGR1decreases expressionISOEgr1 (Rattus norvegicus)6480464CTDCaffeine results in decreased expression of EGR1 mRNAPMID:16771831
EGR1increases expressionISOEgr1 (Mus musculus)6480464CTDCaffeine results in increased expression of EGR1 mRNAPMID:10971643
EGR1multiple interactionsISOEgr1 (Mus musculus)6480464CTD[Cocaine co-treated with Caffeine] results in increased expression of EGR1 mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of EGR1 mRNA]PMID:10971643
EGR1multiple interactionsISOEgr1 (Rattus norvegicus)6480464CTD[Caffeine co-treated with Dextroamphetamine] affects the expression of EGR1 mRNAPMID:16771831
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