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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735582
Species: Mus musculus
RGD Object: Gene
Symbol: Plcb1
Name: phospholipase C, beta 1
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plcb1decreases expressionISOPlcb1 (Rattus norvegicus)6480464CTDCaffeine results in decreased expression of PLCB1 proteinPMID:15998294
Plcb1decreases phosphorylationISOPLCB1 (Homo sapiens)6480464CTDCaffeine results in decreased phosphorylation of PLCB1 proteinPMID:35688186
Plcb1multiple interactionsISOPlcb1 (Rattus norvegicus)6480464CTDCaffeine inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]PMID:15998294
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