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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62246
Species: Mus musculus
RGD Object: Gene
Symbol: Pak2
Name: p21 (RAC1) activated kinase 2
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pak2multiple interactionsEXP 6480464CTD[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA]PMID:20230807
Pak2affects phosphorylationISOPAK2 (Homo sapiens)6480464CTDCaffeine affects the phosphorylation of PAK2 proteinPMID:35688186
Pak2increases activityISOPAK2 (Homo sapiens)6480464CTDCaffeine results in increased activity of PAK2 proteinPMID:19325779
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