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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3696
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc1a1
Name: solute carrier family 1 member 1
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc1a1decreases activityEXP 6480464CTDCaffeine results in decreased activity of SLC1A1 proteinPMID:23262392
Slc1a1multiple interactionsEXP 6480464CTDCaffeine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of SLC1A1 protein]PMID:23262392
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