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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2multiple interactionsEXP 6480464CTDCaffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]PMID:16889759
Drd2affects response to substanceISODRD2 (Homo sapiens)6480464CTDDRD2 polymorphism affects the susceptibility to CaffeinePMID:18305461
Drd2increases response to substanceISODrd2 (Mus musculus)6480464CTDDRD2 protein results in increased susceptibility to CaffeinePMID:11172060
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