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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1multiple interactionsEXP 6480464CTDCaffeine inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]PMID:30377735
Parp1affects cleavageISOPARP1 (Homo sapiens)6480464CTDCaffeine affects the cleavage of PARP1 proteinPMID:19242509
Parp1decreases response to substanceISOPARP1 (Homo sapiens)6480464CTDPARP1 protein results in decreased susceptibility to CaffeinePMID:21840268
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDCaffeine results in increased cleavage of PARP1 proteinPMID:21229324
Parp1increases phosphorylationISOPARP1 (Homo sapiens)6480464CTDCaffeine results in increased phosphorylation of PARP1 proteinPMID:35688186
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD[Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; Caffeine results in increased cleavage of and results in increased expression of PARP1 proteinPMID:16522534 PMID:19490937 PMID:21840268 PMID:22226932
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