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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1618666
Species: Mus musculus
RGD Object: Gene
Symbol: Gsk3a
Name: glycogen synthase kinase 3 alpha
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3adecreases phosphorylationISOGSK3A (Homo sapiens)6480464CTDCaffeine results in decreased phosphorylation of GSK3A proteinPMID:35688186
Gsk3aincreases expressionISOGsk3a (Rattus norvegicus)6480464CTDCaffeine results in increased expression of GSK3A mRNAPMID:25868845
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