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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14000791
Species: Sus scrofa
RGD Object: Gene
Symbol: RYR1
Name: ryanodine receptor 1
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RYR1increases activityEXP 6480464CTDCaffeine results in increased activity of RYR1 protein Caffeine results in increased activity of RYR1 protein mutant form

PMID:11278295
RYR1multiple interactionsEXP 6480464CTDCaffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form] Caffeine promotes the reaction [Ryanodine binds to RYR1 protein] Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]] Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]] Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form] Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]

PMID:11278295
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