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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350223
Species: Homo sapiens
RGD Object: Gene
Symbol: MAP1LC3B
Name: microtubule associated protein 1 light chain 3 beta
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAP1LC3Bincreases cleavageEXP 6480464CTDCaffeine results in increased cleavage of MAP1LC3B proteinPMID:30555576
MAP1LC3Bmultiple interactionsEXP 6480464CTD2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; SIRT3 protein promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]PMID:30555576
MAP1LC3Bincreases cleavageISOMap1lc3b (Mus musculus)6480464CTDCaffeine results in increased cleavage of MAP1LC3B proteinPMID:30555576
MAP1LC3Bmultiple interactionsISOMap1lc3b (Mus musculus)6480464CTD3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]PMID:30555576
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