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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319072
Species: Homo sapiens
RGD Object: Gene
Symbol: PRKDC
Name: protein kinase, DNA-activated, catalytic subunit
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PRKDCaffects phosphorylationEXP 6480464CTDCaffeine affects the phosphorylation of PRKDC proteinPMID:35688186
PRKDCmultiple interactionsEXP 6480464CTDCaffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]]PMID:18158334
PRKDCmultiple interactionsISOPrkdc (Mus musculus)6480464CTDPRKDC protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]PMID:20888899
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