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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316414
Species: Mus musculus
RGD Object: Gene
Symbol: Ryr1
Name: ryanodine receptor 1, skeletal muscle
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ryr1increases activityEXP 6480464CTDCaffeine results in increased activity of RYR1 proteinPMID:16484216
Ryr1multiple interactionsEXP 6480464CTDTRPC3 protein affects the reaction [Caffeine results in increased activity of RYR1 protein]PMID:16484216
Ryr1increases activityISORYR1 (Homo sapiens)6480464CTDCaffeine results in increased activity of RYR1 proteinPMID:21485675
Ryr1increases response to substanceISORYR1 (Homo sapiens)6480464CTDRYR1 gene mutant form results in increased susceptibility to Caffeine; RYR1 protein mutant form results in increased susceptibility to CaffeinePMID:14641996 PMID:15210166 PMID:18719443 PMID:19191329
Ryr1multiple interactionsISORYR1 (Homo sapiens)6480464CTD[Caffeine results in increased activity of RYR1 protein] which affects the localization of Calcium; RYR1 protein polymorphism affects the reaction [Caffeine results in increased secretion of Calcium]PMID:16372898 PMID:21485675
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