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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11003
Species: Mus musculus
RGD Object: Gene
Symbol: Nppa
Name: natriuretic peptide type A
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nppaincreases expressionISONppa (Rattus norvegicus)6480464CTDCaffeine results in increased expression of NPPA mRNAPMID:25093688
Nppamultiple interactionsISONppa (Rattus norvegicus)6480464CTDCaffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA]PMID:15452191 PMID:25093688
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