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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10235
Species: Mus musculus
RGD Object: Gene
Symbol: Bdnf
Name: brain derived neurotrophic factor
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfdecreases expressionISOBdnf (Rattus norvegicus)6480464CTDCaffeine results in decreased expression of BDNF mRNA; Caffeine results in decreased expression of BDNF proteinPMID:35917217
Bdnfmultiple interactionsISOBdnf (Rattus norvegicus)6480464CTD2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of BDNF mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of BDNF protein]; Caffeine inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of BDNF mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of BDNF protein]PMID:26339337 PMID:35917217
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