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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:27727
Term: androstane-3,17-diol
Definition: A 17-hydroxy steroid that has formula C19H32O2.
Chemical ID: MESH:D015113
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingISORGD:25826480464CTDAndrostane-3, 17-diol binds to ESR2 protein

PMID:16452668
increases activityISORGD:25826480464CTDAndrostane-3, 17-diol results in increased activity of ESR2 protein

PMID:8650195
multiple interactionsISORGD:25826480464CTDAndrostane-3, 17-diol inhibits the reaction [Estradiol binds to ESR2 protein]

PMID:8650195
multiple interactionsISORGD:692136480464CTDAndrostane-3, 17-diol analog binds to and results in increased activity of ESR2 protein, Androstane-3, 17-diol binds to and results in increased activity of ESR2 protein, fulvestrant inhibits the reaction [Androstane-3, 17-diol analog binds to and results in increased activity of ESR2 protein], fulvestrant inhibits the reaction [Androstane-3, 17-diol binds to and results in increased activity of ESR2 protein]

PMID:17003281
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.