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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2240
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Car2
Name: carbonic anhydrase 2
Acc ID: CHEBI:27690
Term: acetazolamide
Definition: A thiadiazole that has formula C4H6N4O3S2.
Chemical ID: MESH:D000086
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Car2decreases activityISOCA2 (Homo sapiens)6480464CTDAcetazolamide results in decreased activity of CA2 proteinPMID:11430635 PMID:16858005 PMID:19231207 PMID:21851094 PMID:28117934 PMID:29131470 PMID:29283199 PMID:29457667 PMID:29975450 PMID:29992664 PMID:30291660 PMID:30368973 PMID:30431690 PMID:30537031 PMID:31581370
Car2multiple interactionsISOCA2 (Homo sapiens)6480464CTDAcetazolamide binds to and results in decreased activity of CA2 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA2 protein]PMID:11430635 PMID:17826101 PMID:28251759
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