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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69147
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP9
Name: caspase 9
Acc ID: CHEBI:27656
Term: camptothecin
Definition: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Chemical ID: MESH:D002166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP9decreases expressionEXP 6480464CTDCamptothecin results in decreased expression of CASP9 mRNAPMID:30581319
CASP9increases activityEXP 6480464CTDCamptothecin results in increased activity of CASP9 proteinPMID:34635930
CASP9increases cleavageEXP 6480464CTDCamptothecin results in increased cleavage of CASP9 proteinPMID:10896673 PMID:24823293
CASP9increases expressionEXP 6480464CTDCamptothecin results in increased expression of CASP9 proteinPMID:30885713
CASP9multiple interactionsEXP 6480464CTD[Camptothecin co-treated with FAS protein] results in increased activity of CASP9 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP9 protein; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP9 protein]PMID:15958570 PMID:19633536 PMID:30885713
CASP9increases activityISOCasp9 (Rattus norvegicus)6480464CTDCamptothecin results in increased activity of CASP9 proteinPMID:16263807
CASP9multiple interactionsISOCasp9 (Rattus norvegicus)6480464CTDbenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of CASP9 protein]; Cadmium Chloride inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Cadmium inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]PMID:16263807 PMID:19497415
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