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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620545
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek1
Name: checkpoint kinase 1
Acc ID: CHEBI:27656
Term: camptothecin
Definition: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Chemical ID: MESH:D002166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek1decreases response to substanceISOCHEK1 (Homo sapiens)6480464CTDCHEK1 mRNA results in decreased susceptibility to CamptothecinPMID:25269479
Chek1increases expressionISOCHEK1 (Homo sapiens)6480464CTDCamptothecin results in increased expression of CHEK1 protein modified formPMID:25269479 PMID:30720231
Chek1increases expressionISOChek1 (Mus musculus)6480464CTDCamptothecin results in increased expression of CHEK1 mRNAPMID:22403396
Chek1increases phosphorylationISOCHEK1 (Homo sapiens)6480464CTDCamptothecin results in increased phosphorylation of CHEK1 proteinPMID:21646468 PMID:30555576
Chek1increases phosphorylationISOChek1 (Mus musculus)6480464CTDCamptothecin results in increased phosphorylation of CHEK1 proteinPMID:22403396
Chek1multiple interactionsISOCHEK1 (Homo sapiens)6480464CTD3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form]PMID:25269479 PMID:30720231
Chek1multiple interactionsISOChek1 (Mus musculus)6480464CTD2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]; Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]PMID:22403396
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