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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552456
Species: Mus musculus
RGD Object: Gene
Symbol: Bak1
Name: BCL2-antagonist/killer 1
Acc ID: CHEBI:27656
Term: camptothecin
Definition: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Chemical ID: MESH:D002166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bak1decreases expressionISOBAK1 (Homo sapiens)6480464CTDCamptothecin results in decreased expression of BAK1 mRNAPMID:30581319
Bak1multiple interactionsISOBAK1 (Homo sapiens)6480464CTDFolic Acid inhibits the reaction [Camptothecin results in decreased expression of BAK1 mRNA]PMID:30581319
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