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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:27656
Term: camptothecin
Definition: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Chemical ID: MESH:D002166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTDCamptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BCL2 protein]PMID:25449198
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDCamptothecin results in decreased expression of BCL2 mRNA; Camptothecin results in decreased expression of BCL2 proteinPMID:10692111 PMID:19481069 PMID:24726431 PMID:36394428 PMID:9664115
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 results in decreased susceptibility to CamptothecinPMID:10896673
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDCamptothecin results in increased expression of BCL2 mRNAPMID:24726431
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in decreased expression of BCL2 protein]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in decreased expression of BCL2 protein]; Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BCL2 mRNA]PMID:19481069 PMID:30581319 PMID:36394428
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