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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732023
Species: Homo sapiens
RGD Object: Gene
Symbol: MAP2K1
Name: mitogen-activated protein kinase kinase 1
Acc ID: CHEBI:27641
Term: cycloheximide
Definition: A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.
Chemical ID: MESH:D003513
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAP2K1increases activityISOMap2k1 (Mus musculus)6480464CTDCycloheximide results in increased activity of MAP2K1 proteinPMID:23237828
MAP2K1multiple interactionsISOMap2k1 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cycloheximide results in increased expression of MAP2K1 mRNA]PMID:23237828
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