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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:27641
Term: cycloheximide
Definition: A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.
Chemical ID: MESH:D003513
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10decreases response to substanceEXP 6480464CTDIL10 protein results in decreased susceptibility to CycloheximidePMID:19395591
Il10increases expressionEXP 6480464CTDCycloheximide results in increased expression of IL10 mRNAPMID:19395591
Il10multiple interactionsISOIl10 (Mus musculus)6480464CTDCycloheximide inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]PMID:22183712
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