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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:27641
Term: cycloheximide
Definition: A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.
Chemical ID: MESH:D003513
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDCycloheximide inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA], Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein], Cycloheximide inhibits the reaction [Quercetin results in increased expression of HMOX1 protein], Cycloheximide inhibits the reaction [resveratrol results in increased expression of HMOX1 protein], Cycloheximide inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]

PMID:12472888, PMID:15118350, PMID:15965080, PMID:16647178, PMID:17002867, PMID:24437944
decreases expressionISORGD:107176480464CTDCycloheximide results in decreased expression of HMOX1 protein

PMID:24255720
multiple interactionsISORGD:107176480464CTDCycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Cycloheximide inhibits the reaction [fisetin results in increased expression of HMOX1 protein], Cycloheximide inhibits the reaction [puerarin results in increased expression of HMOX1 protein], Cycloheximide inhibits the reaction [Quercetin results in increased expression of HMOX1 protein], Cycloheximide inhibits the reaction [Triterpenes analog results in increased expression of HMOX1 protein]

PMID:12441344, PMID:15876423, PMID:20060010, PMID:25239868, PMID:30076913
multiple interactionsISORGD:7309016480464CTDCycloheximide inhibits the reaction [Curcumin results in increased expression of HMOX1 protein], Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA], Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein], Cycloheximide inhibits the reaction [Oxygen results in increased expression of HMOX1 mRNA], Cycloheximide inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein], Cycloheximide inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA], Cycloheximide inhibits the reaction [resveratrol results in increased expression of HMOX1 protein], Cycloheximide inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein], Cycloheximide results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]

PMID:15588712, PMID:18357586, PMID:19781563, PMID:20833156, PMID:21840424, PMID:26385185, PMID:9747510
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.