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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352582
Species: Homo sapiens
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: CHEBI:27638
Term: cobalt atom
Definition: A cobalt group element atom that has atomic number 27.
Chemical ID: MESH:D003035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6decreases secretionEXP 6480464CTDCobalt results in decreased secretion of IL6 proteinPMID:17291400
IL6increases secretionEXP 6480464CTDCobalt results in increased secretion of IL6 proteinPMID:10619928 PMID:11518271
IL6multiple interactionsEXP 6480464CTD[tungsten carbide co-treated with Cobalt] results in decreased expression of IL6 mRNAPMID:18078969
IL6increases expressionISOIl6 (Rattus norvegicus)6480464CTDCobalt results in increased expression of IL6 mRNAPMID:22198552
IL6multiple interactionsISOIl6 (Mus musculus)6480464CTD[Zinc co-treated with Nickel co-treated with Cobalt] affects the reaction [Dietary Fats affects the expression of IL6 mRNA]PMID:23503329
IL6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTD[Nickel co-treated with Cobalt co-treated with Tungsten] results in increased expression of IL6 mRNAPMID:22198552
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