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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:2762
Term: antimycin A
Definition: A nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison.
Chemical ID: MESH:D000968
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3increases activityEXP 6480464CTDAntimycin A results in increased activity of CASP3 proteinPMID:24732427
CASP3increases cleavageEXP 6480464CTDAntimycin A results in increased cleavage of CASP3 proteinPMID:32662599 PMID:35430258
CASP3increases expressionEXP 6480464CTDAntimycin A results in increased expression of CASP3 mRNAPMID:35430258
CASP3multiple interactionsEXP 6480464CTD[chromium hexavalent ion co-treated with Antimycin A] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of CASP3 mRNA]; Ascorbic Acid inhibits the reaction [[chromium hexavalent ion co-treated with Antimycin A] results in increased activity of CASP3 protein]; Ascorbic Acid inhibits the reaction [Antimycin A results in increased activity of CASP3 protein]PMID:24732427 PMID:32662599 PMID:35430258
CASP3increases activityISOCasp3 (Rattus norvegicus)6480464CTDAntimycin A results in increased activity of CASP3 proteinPMID:11078377
CASP3increases cleavageISOCasp3 (Mus musculus)6480464CTDAntimycin A results in increased cleavage of CASP3 proteinPMID:24040102
CASP3multiple interactionsISOCasp3 (Mus musculus)6480464CTDNAD inhibits the reaction [Antimycin A results in increased cleavage of CASP3 protein]; Niacinamide promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [Antimycin A results in increased cleavage of CASP3 protein]; splitomicin promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein]PMID:24040102
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