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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2989
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lamp1
Name: lysosomal-associated membrane protein 1
Acc ID: CHEBI:2762
Term: antimycin A
Definition: A nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison.
Chemical ID: MESH:D000968
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lamp1decreases expressionISOLAMP1 (Homo sapiens)6480464CTDAntimycin A results in decreased expression of LAMP1 mRNAPMID:33512557
Lamp1multiple interactionsISOLAMP1 (Homo sapiens)6480464CTD[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNAPMID:28366621
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