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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10681
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:27585
Term: selenomethionine
Definition: A selenoamino acid that is the selenium analogue of methionine.
Chemical ID: MESH:D012645
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1increases activityEXP 6480464CTDSelenomethionine results in increased activity of GPX1 proteinPMID:20659492
Gpx1multiple interactionsEXP 6480464CTDSelenomethionine inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of GPX1 protein]; Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased activity of GPX1 protein]PMID:20659492
Gpx1affects expressionISOGPX1 (Homo sapiens)6480464CTDSelenomethionine affects the expression of GPX1 mRNAPMID:17222674
Gpx1increases activityISOGPX1 (Homo sapiens)6480464CTDSelenomethionine results in increased activity of GPX1 proteinPMID:16632112
Gpx1increases expressionISOGpx1 (Rattus norvegicus)6480464CTDSelenomethionine results in increased expression of GPX1 mRNAPMID:29454614
Gpx1increases expressionISOGPX1 (Homo sapiens)6480464CTDSelenomethionine results in increased expression of GPX1 mRNA; Selenomethionine results in increased expression of GPX1 proteinPMID:16632112 PMID:31585128
Gpx1multiple interactionsISOGpx1 (Rattus norvegicus)6480464CTDSelenomethionine inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of GPX1 protein]PMID:17280487
Gpx1multiple interactionsISOGPX1 (Homo sapiens)6480464CTD[SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of GPX1 mRNAPMID:28495429
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