Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11b3
Name: cytochrome P450, family 11, subfamily b, polypeptide 3
Acc ID: CHEBI:27584
Term: aldosterone
Definition: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Chemical ID: MESH:D000450
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11b3affects chemical synthesisEXP 6480464CTDCYP11B2 protein affects the chemical synthesis of AldosteronePMID:16043663
Cyp11b3affects chemical synthesisISOCyp11b2 (Mus musculus)6480464CTDCYP11B2 protein affects the chemical synthesis of AldosteronePMID:15731365
Cyp11b3affects chemical synthesisISOCYP11B2 (Homo sapiens)6480464CTDCYP11B2 protein affects the chemical synthesis of AldosteronePMID:12525251
Cyp11b3increases chemical synthesisISOCYP11B2 (Homo sapiens)6480464CTDCYP11B2 protein polymorphism results in increased chemical synthesis of Aldosterone; CYP11B2 protein results in increased chemical synthesis of AldosteronePMID:12783697 PMID:16054388 PMID:19900470 PMID:21384875
Cyp11b3multiple interactionsISOCYP11B2 (Homo sapiens)6480464CTD[CYP11B2 protein results in increased hydroxylation of Corticosterone] which results in increased chemical synthesis of AldosteronePMID:21384875
Go Back to source page   Continue to Ontology report