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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:27584
Term: aldosterone
Definition: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Chemical ID: MESH:D000450
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1multiple interactionsISOCol1a1 (Rattus norvegicus)6480464CTD[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA]PMID:27773435
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