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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:27568
Term: selenium atom
Definition: A chalcogen that has formula Se.
Chemical ID: MESH:D012643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects activityISORGD:104736480464CTDSelenium affects the activity of NQO1 protein

PMID:18279678
decreases activityISORGD:104736480464CTDSelenium results in decreased activity of NQO1 protein

PMID:28810182
increases expressionISORGD:25036480464CTDSelenium deficiency results in increased expression of NQO1 mRNA

PMID:11444866
multiple interactionsISORGD:25036480464CTD[Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of NQO1 mRNA, Selenium promotes the reaction [Plant Extracts results in increased activity of NQO1 protein]

PMID:11444866, PMID:19650632
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.