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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDArsenic results in increased expression of NQO1 mRNA, Arsenic results in increased expression of NQO1 protein

PMID:19945496, PMID:27413109
increases activityISORGD:104736480464CTDArsenic results in increased activity of NQO1 protein

PMID:15337587
increases expressionISORGD:104736480464CTDArsenic results in increased expression of NQO1 mRNA, Arsenic results in increased expression of NQO1 protein

PMID:15337587, PMID:19786557, PMID:23000044
multiple interactionsISORGD:104736480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in decreased expression of NQO1 mRNA, Arsenic promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], Arsenic promotes the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA], Arsenic promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA], NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of NQO1 mRNA]

PMID:10972992, PMID:15337587, PMID:23000044, PMID:31238026
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.