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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735618
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3affects response to substanceEXP 6480464CTDNOS3 gene polymorphism affects the susceptibility to ArsenicPMID:16076760
NOS3decreases expressionEXP 6480464CTDArsenic results in decreased expression of NOS3 proteinPMID:25110733
NOS3decreases activityISONos3 (Rattus norvegicus)6480464CTDArsenic results in decreased activity of NOS3 proteinPMID:22120977
NOS3decreases expressionISONos3 (Rattus norvegicus)6480464CTDArsenic results in decreased expression of NOS3 mRNAPMID:22120977
NOS3increases phosphorylationISONos3 (Mus musculus)6480464CTDArsenic results in increased phosphorylation of NOS3 proteinPMID:30822117
NOS3multiple interactionsISONos3 (Rattus norvegicus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NOS3 protein; Acetaminophen inhibits the reaction [Arsenic results in decreased expression of NOS3 mRNA]; Arsenic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NOS3 protein]PMID:22120977 PMID:33026618
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